Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a coordinated attack on an underground arms cache in Syrian territory used by the IS group, as stated by the UK Ministry of Defence.
The location, located using intelligence, was assessed as housing weapons and explosive materials, the announcement noted, and was located in mountains just north of Palmyra in central Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a series of approach shafts leading to the depot... preliminary assessments are that the strike was effective," officials stated.
There was no indication of any civilian impact in the operation conducted Saturday night and all the aircraft returned safely, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - imposed militant control over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This strike underscores the UK's leading role, and resolve to operate in unison with allied nations, to eradicate any re-emergence of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary the minister stated.
British military aircraft have conducted overwatch operations over Syrian airspace to "deter any attempted resurgence" of the group subsequent to its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank all the members of British forces participating in this operation for their professionalism and their courage," the Defence Secretary added. "They were among numerous British personnel deployed over Christmas and New Year. This operation, to eliminate terrorist threats who endanger our security, highlights how British military are always on standby, all year round, ensuring Britain's security domestically and powerful internationally."
Last December, the United States armed forces conducted what it called a "large-scale strike" against IS targets in the country, after an attack resulted in the deaths of two US troops and a civilian linguist in Palmyra.
The United Nations says IS still boasts between 5,000 and 7,000 combatants in Syria and Iraq.